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OCR GCSE Biology A (J247) · B6 Global challenges
Mini-Lesson

Global challenges

This mini-lesson covers OCR B6 — Global challenges: sampling & monitoring ecosystems, human impact, food security, health & disease, pathogens and the immune system, drug development and biotechnology.

disease& immunityfood &environmentdrugs &biotech how biology tackles the big problems facing people and the planet

Work through each screen, answer the questions as you go and collect ⭐ stars. Watch for the Higher tier flags. Press Start when you're ready.

Sampling & monitoring ecosystems

Sampling & monitoring

We monitor ecosystems to spot changes and pollution:

  • Quadrats (placed randomly) and transects (along a line) estimate populations and how they change.
  • Indicator species reveal pollution — e.g. lichens and mayfly larvae only survive in clean air/water.
  • Scale up the mean per quadrat to estimate the whole population; more, random samples = more reliable.

Indicator species: their presence or absence is a quick, cheap sign of environmental quality.

Quick check

What is an indicator species?

?Why are lichens useful as indicator species?
Human impact & food security

Human impact & food security

A growing human population increases demand and impact:

  • Human impact: deforestation, pollution, and greenhouse-gas emissions reduce biodiversity and change the climate.
  • Food security is having enough safe food for everyone. It is threatened by a rising population, changing diets, pests, disease and climate change.
  • Ways to improve yield: fertilisers, pest control, and biotechnology (e.g. GM crops).

Sustainability: we must increase food production without permanently damaging ecosystems or biodiversity.

Health · pathogens

Health, disease & pathogens

Health is a state of physical and mental wellbeing. Diseases can be:

  • Communicable (infectious) — caused by pathogens that spread between organisms.
  • Non-communicable — not spread; e.g. many cancers, heart disease.

The four pathogen groups: bacteria (e.g. Salmonella), viruses (e.g. measles, HIV), fungi (e.g. rose black spot) and protists (e.g. malaria, spread by mosquitoes).

Bacteria vs viruses: bacteria release toxins that make you feel ill; viruses invade cells and reproduce inside them, damaging the cell. Antibiotics kill bacteria but not viruses.

Quick check

What do antibiotics kill?

?A patient has a viral infection. Why won't antibiotics help?
The immune system

The immune system & vaccination

White blood cells defend the body against pathogens by:

  • Phagocytosis — engulfing and digesting pathogens.
  • Producing antibodies that lock onto specific pathogens.
  • Producing antitoxins that neutralise toxins.

Vaccination: a harmless form of the pathogen (antigen) is introduced, so white blood cells make antibodies and memory cells. If the real pathogen invades later, the response is faster and larger — you are immune.

Herd immunity: if enough people are vaccinated, the pathogen can't spread easily, protecting those who aren't vaccinated.

Quick check

How does a vaccine work?

?How does a vaccine protect you from a disease?
Match it

Match each pathogen to its group

Tap a disease, then its pathogen type.

Statement
Answer
Drug development

Developing new drugs

New drugs are tested in stages before use:

  • Preclinical — tested on cells, tissues and then animals.
  • Clinical trials — tested on healthy volunteers (for safety) then patients (for safety and effectiveness), finding the best dose.
  • Placebo and double-blind trials (neither doctor nor patient knows who gets the real drug) reduce bias.

Why so thorough? testing checks a drug is safe, effective and given at the right dose before it reaches patients.

Quick check

What is a double-blind trial?

?In a double-blind drug trial, who knows which patients receive the real drug?
Biotechnology

Biotechnology & genetic engineering

Biotechnology uses living organisms to make useful products:

  • Genetic engineering — transferring a gene from one organism to another (e.g. inserting the human insulin gene into bacteria so they make insulin).
  • GM crops — modified for pest resistance or higher yield to help food security.
  • Enzymes and microorganisms are used to make foods, medicines and fuels.

Evaluate GM: benefits include higher yields and insulin production, but there are concerns about long-term effects, ethics and reduced biodiversity.

Sort it

Sort each into its group

Tap each item, then tap which theme it belongs to.

🦠 Fighting disease

🌾 Food & environment

🧫 Biotechnology

Recap

The big ideas to know

Monitoring: quadrats, transects & indicator species (e.g. lichens)

Food security: enough safe food; threatened by population, pests, climate

Pathogens: bacteria · viruses · fungi · protists (communicable disease)

Immune system: phagocytosis, antibodies, antitoxins; vaccines make memory cells

Drug development: preclinical → clinical trials; double-blind + placebo

Biotechnology: genetic engineering; insulin from bacteria; GM crops

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