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Cambridge IGCSE Biology (0610) · Gas exchange & respiration
Mini-Lesson

Gas exchange & respiration

This mini-lesson walks you through Cambridge IGCSE Gas exchange & respiration: gas exchange surfaces and the lungs, aerobic & anaerobic respiration and their equations, oxygen debt, and the effect of exercise.

gas exchange in the alveoli aerobic respiration releases most energy anaerobic respiration no oxygen · less energy oxygen in, then energy released inside cells

Work through each screen, answer the questions as you go (some wordy, some calculations) and collect ⭐ stars. Watch for the Key term flags. Press Start when you're ready.

Gas exchange · the lungs

Gas exchange surfaces & the lungs

We breathe air down the trachea, which branches into bronchi and then tiny bronchioles, ending in millions of air sacs called alveoli. This is where gas exchange happens:

  • Oxygen diffuses from the air in the alveoli into the blood.
  • Carbon dioxide diffuses from the blood into the alveoli, to be breathed out.
alveolus (air sac) O₂ in CO₂ out blood capillary ✔ large surface area (many alveoli) ✔ thin walls — short diffusion path ✔ moist lining for gases to dissolve ✔ rich blood supply — steep gradient
Alveoli are adapted for fast diffusion: huge surface area, thin moist walls and a good blood supply.

Adaptations to learn: large surface area, thin (one-cell) walls, moist lining and a rich blood supply — all speed up diffusion of gases.

Quick check

Which way do the gases go?

?At an alveolus, which describes the correct direction of diffusion for the two gases?
Respiration · aerobic

Aerobic respiration

Respiration is the release of energy from food (glucose) inside every living cell. Aerobic respiration uses oxygen and releases a large amount of energy. It mostly happens in the mitochondria.

glucose + oxygen → carbon dioxide + waterC₆H₁₂O₆ + 6O₂ → 6CO₂ + 6H₂O (+ energy released)

The energy released is used for muscle contraction, growth, making molecules, active transport, and keeping warm.

Careful wording: respiration releases (transfers) energy — it does not "make" or "produce" energy. Energy cannot be created; it comes from the glucose.

Respiration · anaerobic

Anaerobic respiration

Anaerobic respiration releases energy from glucose without oxygen. It releases much less energy per glucose than aerobic respiration, because the glucose is only partly broken down.

in muscles: glucose → lactic acid+ a small amount of energy released

In yeast and plants, anaerobic respiration is different — it forms alcohol (ethanol) and carbon dioxide (this is fermentation, used in brewing and bread-making):

in yeast: glucose → alcohol + carbon dioxideC₆H₁₂O₆ → 2C₂H₅OH + 2CO₂ (fermentation)
aerobic — lots of energy anaerobic — less energy same glucose, very different energy yield
Anaerobic respiration is a quick backup, but it wastes most of the glucose's energy.
Sort it

Aerobic or anaerobic?

Tap a statement, then tap the type of respiration it describes. (Some are true of both.)

🔁 Both

🌬️ Aerobic

🚫 Anaerobic

Key term · oxygen debt

Oxygen debt & exercise

During hard exercise, muscles can't get enough oxygen, so they respire anaerobically, building up lactic acid. This causes muscle fatigue and cramp.

The extra oxygen needed afterwards to break down this lactic acid is called the oxygen debt. This is why you keep breathing hard and fast after you stop exercising — to "repay" the debt.

hard exercise not enough O₂ anaerobic in muscles → lactic acid builds up breathe hard afterwards extra O₂ removes lactic acid = oxygen debt heart rate & breathing rate also rise to deliver O₂ and remove CO₂
Exercise raises breathing rate, heart rate and depth of breathing to supply more oxygen and remove CO₂.
Quick check

Why keep panting?

?After a sprint, an athlete keeps breathing deeply for several minutes. What is the main reason?
Calculate

Your turn — breathing rate

1A student takes 9 breaths in 30 seconds while resting. Calculate the breathing rate in breaths per minute.
/min
Hint: breaths per minute = breaths ÷ seconds × 60 = 9 ÷ 30 × 60.
Calculate

Your turn — effect of exercise

2At rest the breathing rate is 18 breaths/min. After exercise it rises to 36 breaths/min. Calculate the percentage increase.
%
Hint: % increase = (36 − 18) ÷ 18 × 100.
Quick check

Which releases more energy?

?Compared with anaerobic respiration, how much energy does aerobic respiration release from the same amount of glucose, and why?
Match it

Match each idea to its term

Tap a description on the left, then its matching term on the right.

Description
Term
Quick check

Why so many alveoli?

?The lungs contain millions of tiny alveoli rather than a few large air sacs. What is the main benefit of this?
Recap

The big ideas to know

Lungs: trachea → bronchi → bronchioles → alveoli (gas exchange site)

Alveoli: large surface area, thin moist walls, good blood supply

Gas exchange: O₂ into blood, CO₂ out of blood, by diffusion

Aerobic: glucose + oxygen → carbon dioxide + water (lots of energy)

Anaerobic (muscle): glucose → lactic acid (little energy)

Anaerobic (yeast): glucose → alcohol + carbon dioxide (fermentation)

Oxygen debt: extra O₂ needed after exercise to break down lactic acid

You've covered the whole of Cambridge IGCSE Gas exchange & respiration. Press Finish to see your score.

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