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IB Diploma Biology SL · Theme D: Continuity & Change — Molecules & Cells
Mini-Lesson

Continuity & Change: Molecules & Cells

Genetic information must be copied, read and passed on. This SL lesson covers D1.1 DNA replication, D1.2 Protein synthesis, D1.3 Mutation, D2.1 Cell & nuclear division and D2.3 Water potential.

You will follow replication, transcription and translation, and use codon and water-potential calculations.

Work through each screen, answer the questions as you go (some are wordy, some are calculations) and collect ⭐ stars. Press Start when you are ready.

D1.1 DNA replication

DNA replication

DNA is copied semi-conservatively: the double helix unwinds (helicase), and each strand acts as a template. DNA polymerase adds complementary nucleotides (A-T, G-C).

Each daughter molecule keeps one original strand and gains one new strand — the basis of genetic continuity.

D1.2 Protein synthesis

From gene to protein

Genes are expressed in two stages:

  • Transcription (nucleus): RNA polymerase copies a gene into mRNA.
  • Translation (ribosome): the mRNA codons are read three bases at a time; tRNA brings the matching amino acid, building a polypeptide.

The genetic code is a triplet code, degenerate (most amino acids have several codons) and nearly universal — evidence of shared ancestry.

Calculate

Your turn — calculate

1The coding region of an mRNA is 300 nucleotides long. Calculate the maximum number of codons it contains.
codons
Hint: each codon is 3 nucleotides, so 300 ÷ 3.
Quick check

Question

?DNA replication is described as semi-conservative because each new molecule contains...
D1.3 Mutation

Mutation and change

A mutation is a change in the DNA base sequence. A point mutation changes one base; insertions or deletions can cause a frameshift.

Mutations are the ultimate source of new alleles and genetic variation — the raw material for evolution. Mutagens (UV, some chemicals) raise the mutation rate.

D2.1 Cell division

Cell and nuclear division

The cell cycle is interphase (growth and DNA replication) then division. Mitosis produces two genetically identical diploid daughter nuclei for growth and repair.

Meiosis (covered under reproduction) halves chromosome number to make varied gametes.

Uncontrolled mitosis, from mutations in genes controlling the cell cycle, can lead to a tumour.

Calculate

Your turn — calculate

2A plant cell has a solute potential Ψs of −450 kPa and a pressure potential Ψp of +200 kPa. Using Ψ = Ψs + Ψp, calculate its water potential Ψ.
kPa
Hint: Ψ = −450 + 200.
Sort it

Sort each item into its group

Sort each statement into the correct process.

Transcription

Translation

DNA replication

Quick check

Question

?The genetic code is described as degenerate because...
Quick check

Question

?A plant cell placed in pure water becomes turgid because water enters by osmosis, moving...
Match it

Match each item to its partner

Match each term to its correct description.

Item
Partner
Quick check

Question

?Mitosis produces daughter cells that are...
Recap

The big ideas to take away

D1.1: semi-conservative replication conserves genetic information

D1.2: transcription (mRNA) then translation (codons, tRNA) make proteins

D1.3: mutation changes the base sequence and creates variation

D2.1 / D2.3: mitosis gives identical diploid cells; Ψ = Ψs + Ψp

Press Finish to see your score.

🏆

Mini-lesson complete!

⭐⭐⭐

You have worked through Theme D: Continuity & Change — Molecules & Cells for IB Diploma Biology. 🎉

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